Presentation

Alexis Mauricio Núñez Núñez, Verónica Fernanda Flores Hernández, Diana Velasteguí Hernández, Fabricio Alejandro Vásquez de la Bandera Cabezas
Technical University of Ambato

Introduction: It has been proven that diet can cause structural and functional changes in the brain. At present, the effects of the type of diet on cognition are widely studied topics and intermittent fasting ( AI ) is a type of dietary restriction that has effects on weight loss, cardiovascular, endocrine and immune functioning, the risk of developing Alzheimer's and other diseases. However, its positive effects remain controversial. Objective: To determine the effects of AI on the hippocampus and memory. Method: A systematic review was carried out following the PRISMA model of 8 articles obtained from Pubmed , Web of Science and Psyinfo . Results: Mice that were fed AI had: (1) decreased CBR1 agonists, (2) increased levels of brain neurotrophic factor ( BNDF ) protein and postsynaptic density complex (PSD95) protein, ( 3) decreased insulin signaling pathway and (4) increased volume in the dentate gyrus and dendritic spines in CA1 of the hippocampus. In addition, the results of the memory tests showed better performance in short-term memory and long-term spatial memory. On the other hand, people fed by AI presented lower scores in the similarity test. Conclusions: Beneficial effects were observed at a biochemical, structural, and functional level in the hippocampus, and memory in animal models. However, in humans the results are not consistent with those of the animal model, although no disadvantages are observed, the advantages are not evident either.

Keywords:intermittent fasting, hippocampus, short-term memory, long-term spatial memory